Sandy first met SpongeBob when he saw her wrestling a giant clam and ran down to save her. Since then, Sandy has been one of SpongeBob's best friends, and she enjoys various activities with him such as karate. She also enjoys going to Goo Lagoon with him and lifting weights. Despite their tight friendship, Sandy has gotten annoyed by SpongeBob in various episodes, such as "Sandy's Rocket" and "Texas."
File:Imprrsanating.pngSandy gets angry at Patrick.Patrick and Sandy have a close friendship. They usually get along very well though Sandy has frequently been annoyed by Patrick's utter stupidity no doubt due to her higher intellect. On occasion, Patrick has angered her to the point where she has threatened to attack him, as shown in the episodes "Texas" and "Survival of the Idiots." In "Patrick SmartPants," she gets along well with Patrick until he gets a little arrogant thinking that she's dumb.
Sandy and Squidward have had limited interactions. Squidward doesn't seem to know who she is on a few occasions. In "SpongeBob SquarePants vs. The Big One," Squidward asks "Who are you?" and in "Rodeo Daze," he mistakes her name for "Sally." However, Sandy is happy to help Squidward, such as in "Squidtastic Voyage" when she helps him revive his clarinet reed from his throat. Then in The SpongeBob Movie: Sponge Out of Water, she was seen carrying him to safety when he was almost crushed by skating humans and letting him ride on her back when they're chasing Burger Beard. At times like in the episode "Patrick! The Game," Sandy can easily get annoyed by Squidward's attitude towards things, like his attitude towards Patrick's game.
Sandy and Mr. Krabs generally do not talk to each other. However, there are a few episodes in which they do interact. When they do, they seem to be very nice to each other and they never really argue or fight. However, when they first met, he expressed a prejudice towards land mammals. At the end of the same episode he was impressed by her cooking skills and hired her to work with SpongeBob. In the episode "Surf N' Turf," Mr. Krabs, who's sent to help Sandy, constantly destroys any ship in the bottle she makes, he later then turns Sandy's treedome into a huge ship in a bottle and attempts to enter it into the contest, but fails in the end and Sandy forces him to restore her treedome.
Sandy and Karen have become good friends, sharing an interest in science. The two meet in "Perfect Chemistry," and Sandy calls Karen beautiful. In "Frozen Face-Off," Sandy helps save Karen from being frozen. In "Salsa Imbecilicus," the two team up to create a university. In "Girls' Night Out," Sandy, Karen, and Mrs. Puff spend a night out together, and the three refer to one another as "Gal Pals" throughout the episode.
Although they barely interact, Sandy tends to dislike Plankton, such as in "Someone's in the Kitchen with Sandy when he steals her fur to obtain the Krabby Patty secret formula. However, they do get along in "Perfect Chemistry," as she is impressed by his lab and she helps him with his invention, and vice versa. She also states she knew that he was going to steal the Krabby Patty formula. They are also seen playing chess together in "Mimic Madness."
Sandy and Pearl have a stable relationship. In "Bubble Troubles," Pearl helps Sandy breathe air, saying "I guess us mammals have to stick together." Pearl goes to Sandy's birthday party in the episode "Feral Friends." and wants her to stay in Bikini Bottom in "Texas." In "A Cabin in the Kelp," Pearl joins the Gal Pals with Karen, Sandy, and Mrs. Puff.
Gary the Snail
Sandy and Gary barely interact with each other, but they do seem to know each other. In "Culture Shock," Sandy says Gary has "such a way with words."
Sandy and Larry the Lobster seem to get along well. They have been seen hanging out together at Goo Lagoon in episodes such as "Ripped Pants" and "MuscleBob BuffPants."
